Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa
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چکیده
منابع مشابه
Cyclic-di-GMP levels affect Pseudomonas aeruginosa fitness in the presence of imipenem.
A large number of genes coding for enzymes predicted to synthesize and degrade 3'-5-cyclic diguanylic acid (c-di-GMP) is found in most bacterial genomes and this dinucleotide emerged as an intracellular signal-controlling bacterial behaviour. An association between high levels of c-di-GMP and antibiotic resistance may be expected because c-di-GMP regulates biofilm formation and this mode of gro...
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4 Department of International Health, Immunology and Microbiology, Faculty of Health and 5 Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 6 Department of Microbiology, University of Washington, Seattle, WA 98195-7242, USA. 7 Medicinal Chemistry Research, Lundbeck Research Denmark, H. Lundbeck A/S, Ottiliavej 9, DK8 2500 Valby, Denmark. 9 Department of Chemistry, Technical Univ...
متن کاملCyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.
The cyclic dinucleotides 3'-5'diadenylate (c-diAMP) and 3'-5' diguanylate (c-diGMP) are important bacterial second messengers that have recently been shown to stimulate the secretion of type I Interferons (IFN-Is) through the c-diGMP-binding protein MPYS/STING. Here, we show that physiologically relevant levels of cyclic dinucleotides also stimulate a robust secretion of IL-1β through the NLRP3...
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Vibrio cholerae is a facultative human pathogen. The ability of V. cholerae to form biofilms is crucial for its survival in aquatic habitats between epidemics and is advantageous for host-to-host transmission during epidemics. Formation of mature biofilms requires the production of extracellular matrix components, including Vibrio polysaccharide (VPS) and matrix proteins. Biofilm formation is p...
متن کاملYfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa
During long-term cystic fibrosis lung infections, Pseudomonas aeruginosa undergoes genetic adaptation resulting in progressively increased persistence and the generation of adaptive colony morphotypes. This includes small colony variants (SCVs), auto-aggregative, hyper-adherent cells whose appearance correlates with poor lung function and persistence of infection. The SCV morphotype is strongly...
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ژورنال
عنوان ژورنال: Biology
سال: 2021
ISSN: 2079-7737
DOI: 10.3390/biology10060519